ORU improved its Southland Conference record to 14-9 and 13 21-27 overall, while the Cowboys fell to 21-27 on the season with an 8-15 SLC mark.
Freshman hurler Guillermo Trujillo (2-0) earned his second victory of the season out of the pen as he replaced Drew Bowen following a weather delay. Trujillo threw 3.1 innings with six hits and allowed one run to score, while Bowen finished three innings, gave up just two hits and an earned run.
Kurt Giller replaced Trujillo in the top of the seventh and allowed just one hit in the final 2.2 innings.
Migliaccio got the first big fly of the afternoon with the Cowboys leading the Golden Eagles, 2-1, in the bottom of the fourth. After Williams reached on an error to start the inning, Migliaccio turned on the first pitch of his at bat for a two-run home run, his second of the season.
After recording just four hits in the series opener on Friday, the offense rattled off 11 hits in the contest.
ORU also made McNeese pay for a couple mistakes, turning two errors into runs, including the first Golden Eagle run in the bottom of the third. With Kevin Cho standing on third, Jose Trevino hit a dribbler back to the pitcher that was misplayed, which allowed the runner to score.
Soon after the run was scored, a small thunderstorm sent the contest into a one-hour and 27 minute weather delay.
Out of the delay, in the top of the fourth, Lucas Quary blasted the second home run of the afternoon by the Cowboys. Andrew Guillotte started the game for McNeese with a solo home run.
In the home half of the sixth, Domenico stepped in with the bases loaded and delivered a one-out singled to right, driving in Migliaccio and Graham McIntyre. Williams then delivered the second ORU homer in the game in the seventh to straight away center to plate Boss.
Tyler Parke (3-2) entered the game for the Cowboys after the delay and took the loss in 2.1 innings of work. He allowed four runs, three of which were earned, on five hits.
The Golden Eagles and Cowboys play the series victory on Sunday afternoon at 1 p.m at J.L. Johnson Stadium with ORU Senior Day festivities immediately following the game.